diff --git a/base/plugins.cpp b/base/plugins.cpp
index 3e47a537176..37daf1e7660 100644
--- a/base/plugins.cpp
+++ b/base/plugins.cpp
@@ -32,6 +32,8 @@
 
 #include "base/detection/detection.h"
 
+#include "engines/advancedDetector.h"
+
 // Plugin versioning
 
 int pluginTypeVersions[PLUGIN_TYPE_MAX] = {
@@ -722,6 +724,9 @@ DetectionResults EngineManager::detectGames(const Common::FSList &fslist) const
 	// run detection for all of them.
 	plugins = getPlugins(PLUGIN_TYPE_ENGINE_DETECTION);
 
+	// Clear md5 cache before each detection starts, just in case.
+	MD5Man.clear();
+
 	// Iterate over all known games and for each check if it might be
 	// the game in the presented directory.
 	for (iter = plugins.begin(); iter != plugins.end(); ++iter) {